08-09-2010
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Akciğer Arşivi

 

ORIGINAL RESEARCH ARTICLES

Diagnostic Value Of Pleural Fluid Pge2 Levels In Malignant Pleural Effusion

Dr. Yusuf AYDEMİRa, Dr. Fikret KANATb, Dr. Oktay İMECİKb

aGöğüs Hastalıkları Kliniği, Konya Numune Hastanesi, bGöğüs Hastalıkları AD, Konya Selçuk Üniversitesi Meram Tıp Fakültesi, Konya

Objective: This study was carried on to evaluate the utility of Prostaglandin E2 (PGE2) in the differential diagnosis of malignant pleural effusion. Material and Methods: The study included 100 patients with the pleural effusions, who were examined in The Chest Diseases and Tuberculosis department of Meram Medical School of Medicine in Selcuk University. The patients were assessed in 3 groups, which were transudates-exudates according to the diagnosis, malignant-benign effusions and specific diagnosis group (lung cancer, mesothelioma, metastatic lung cancer, tuberculosis, parapneumonic effusion and transudates). The pleural fluid PGE2 levels were determined by EIA method. Results: We found the mean pleural fluid PGE2 level of 322.1 pg/ml in lung cancer group and U was higher than all other group. However, difference of the mean pleura PGE2 levels of malignant (206.75 pg/ml) and benign (195.66 pg/ml) groups was not statistically significant. The pleural fluid PGE2 levels in the patients with lung cancer groups differed significantly from the parapneumonic (p= 0.02), mesotelioma (p= 0.002), methastatic lung cancer (p< 0.001) and transuda (p< 0.001) groups. However, difference of the mean pleural fluid PGE2 levels of lung cancer and tuberculosis groups was not statistically significant (p> 0.5). Conclusion: Use of PGE2 for the seperation of malignant and benign effusions is not suitable. Because low levels of PGE2 may be found in mesothelioma and methastatic cancer and may be found higher levels in tuberculosis. We have opinion that it may be helpful in the discrimination of pleural effusions in suspicious conditions.

Keywords: Lung neoplasms; pleural effusion, malignant; prostaglandin E

Turkiye Klinikleri Arch Lung 2009;10(2):51-6
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