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Chronic Necrotizing Pulmonary Aspergillosis In A Patient With Asthma: Case Report
Hilal ERMİŞ, MDa, Nazan ŞEN, MDa, Meltem KARATAŞLI, MDa, Tuba CANPOLAT, MDb, Füsun ÖNER EYÜBOĞLU, MDc
Departments of aChest Diseases, bPathology, cChest Diseases, Başkent University Faculty of Medicine, Ankara
Chronic necrotizing pulmonary aspergillosis is a rare fungal infection that is characterized by slow progression and local invasion. It is most commonly seen in patients with impaired lung parenchyma and mild immunodeficiency. A 81 years old female patient with an established diagnosis of asthma for 5 years was admitted to our clinic with complaints of cough and sputum. Posteroanterior chest radiograph showed an irregular opacity at the right middle zone. Thorax CT revealed an irregular pleural based lesion with central cavitation. Histopathological examination of the transthoracic biopsy specimen showed aspergillus hyphae with tissue invasion. The patient was treated with voriconazole. At the end of a total of 6 months therapy, control CT revealed no lesion. We reported this case to emphasize that the chronic necrotizing pulmonary aspergillosis may develop in the immunocompetent patients with asthma resistant to the treatment. Early diagnosis of aspergillus infection in these particular patients is essential for the control of the disease to decrease mortality.Keywords: Aspergillosis, asthmaTurkiye Klinikleri Arch Lung 2009;10(2):63-6
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